◆ Innovative PRP technology utilizes autologous blood separation to obtain high-concentration platelet-rich plasma.
Platelet-rich plasma (PRP) is a plasma fraction derived from autologous blood that is enriched with a high concentration of platelets; the concentrations of platelets and the growth factors they release in PRP are substantially higher than those in whole blood.
◆PRP is rich in multiple high-concentration growth factors and plays an important role in tissue regeneration and repair.
• Platelet-derived growth factor (PDGF)
Enhances collagen synthesis and osteocyte proliferation
Activate macrophages and enhance TGF-β secretion
Binding to TGF-β promotes bone mineralization.
• Insulin-like growth factor (IGF)
Promotes the regeneration and repair of bones, blood vessels, skin, and other tissues.
Stimulates collagen synthesis in conjunction with PDGF
• Transforming growth factor-β (TGF-β)
Enhances type I collagen synthesis, thereby promoting the repair of tissues such as skin, bone, and muscle.
Promotes angiogenesis and connective tissue regeneration
At the site of bone injury, stimulation of osteoblast proliferation promotes bone formation.
• Epidermal Growth Factor (EGF)
Stimulate angiogenesis
Stimulates epithelial formation and significantly shortens the healing process.
• Vascular Endothelial Growth Factor (VEGF)
Stimulates angiogenesis, migration, and mitosis in endothelial cells.
Deliver nutrients to the injured area and increase blood flow.
• Fibroblast growth factors (FGFs)
is one of the most potent mitogens
Stimulate the growth and differentiation of chondrocytes and osteoblasts.
Participates in the angiogenesis process
◆The clinical value of PRP in multiple therapeutic areas is now firmly supported by substantial evidence.
| Musculoskeletal and Joint Diseases | |||||
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| Osteoarthritis | Fracture | Meniscus injury | Anterior Cruciate Ligament Rupture | Patellar dislocation | |
| Skin injury | Eye diseases | Dentistry | ||||
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| Extensive skin injury | Burn | MRSA-Infected Skin Wounds | Corneal ulcer | Dry Keratoconjunctivitis | Periodontal disease | Implantation or replantation after tooth extraction |
◆ Clinical Case Studies of PRP in Veterinary Orthopedics
An 11-month-old female Poodle presented with nonunion of distal radius and ulna fractures. Following failure of the initial surgery, bone resorption and necrosis developed. A second procedure was performed, consisting of autologous coccygeal bone grafting combined with PRP therapy. Bone union was observed at 13 weeks post-grafting, with complete union achieved by week 18.
• Detailed postoperative X-ray images of the Great Poodle in November
◆ Clinical Case Studies on the Use of PRP for Pet Trauma
A 2-year-old domestic barn cat developed brittle skin syndrome, resulting in multiple traumatic injuries. Following one week of combined treatment with PRP injections and cefazolin, the wounds had largely healed.
◆ Clinical Application Cases of PRP in Veterinary Ophthalmology
A 15-year-old male Bichon Frise presented with a large corneal ulcer in the left eye accompanied by secondary mild uveitis; treatment with PRP eye drops for 9 days resulted in complete resolution.
| July 20, 2024 Extensive corneal ulcer in the left eye, with PRP treatment administered. |
July 22, 2024 Day 3 of PRP Treatment |
July 24, 2024 Day 5 of PRP Treatment |
July 28, 2024 Day 9 of PRP Treatment |
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| Conjunctival hyperemia, irregular corneal surface, and miosis. | |||
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| Fluorescein sodium staining reveals extensive corneal staining. |
◆ Clinical Case Studies of PRP Application in Veterinary Dentistry
• A 4-year-old stray country cat, after undergoing full-mouth extraction due to tail-mouth inflammation, lost its appetite and became lethargic; three days after receiving PRP therapy, its appetite returned.
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| Feeling lethargic after tooth extraction, Complete loss of appetite |
Injection of autologous PRP into the oral mucosa | Noticeable swelling after injection | Appetite returned on the third day after the injection. The swelling completely subsided after one week. |
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Keywords
Platelet-Rich Plasma Preparation System
Category
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Nanjing Runyou Biotechnology Co., Ltd.
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